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[seventy two] Nicotine brings about smooth muscle mass leisure by motion of endogenous nitric oxide for a nonadrenergic noncholinergic neurotransmitter.[73] The decrease in tone of your colon and gastric motility and diminished reduce tyson-2-0-heavyweight-7000-puffs-5-nicotine esophageal sphincteric pressure could possibly be The rationale of greater incidence of GERD.[74]